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The effect of osteopathic manipulative treatment on immune response to the influenza vaccine in nursing homes residents: a pilot study

Journal: Alternative Therapies In Health And Medicine Date: 2004/07, 10(4):Pages: 74-6, type of study: randomized controlled trial

Full text    (http://www.alternative-therapies.com/index.cfm/fuseaction/archives.main)

Keywords:

aged [42]
antibodies [2]
immunoglobulin G [1]
immunoglobulin M [1]
influenza A vaccine [1]
osteopathic manipulative treatment [2973]
OMT [2951]
pilot project [15]
randomized controlled trial [710]

Abstract:

A randomized controlled pilot study was designed to test the hypothesis that osteopathic manipulative treatment (OMT) can improve the immune response to the influenza vaccine in the elderly, measured by evaluating antibody titers and clinical outcomes during the 1999-2000 flu season. A total of 22 eligible subjects were recruited from two nursing home facilities in Kirksville, Mo. Eleven subjects were randomized to each of two groups, one group received OMT treatments, and the second received sham treatments consisting mainly of light touch. The mean ages [± standard deviation (SD)] for the OMT and sham groups were 84.8 (+5.3) years and 85.2 (+6.6) years, respectively. All participants, except one unknown status in each group, had been vaccinated the previous year with the same trivalent inactivated influenza vaccine used during the current study. There were no statistically significant differences between the groups on age, gender, race, history of dementia, or diagnosis of COPD, hypertension, coronary heart disease, or congestive heart failure. However, five subjects in the OMT group and no subjects in the sham group had a prior history of stroke, a difference that was significant (P = 0.04).


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