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Osteopathic Manipulative Therapy Effects on Prolonged Post-COVID Olfactory Dysfunction

Journal: PM&R Date: 2024/11, 16(S1):Pages: S22–S23. doi: Subito , type of study: pretest posttest design

Free full text   (https://onlinelibrary.wiley.com/doi/10.1002/pmrj.13305)

Keywords:

anosmia [4]
conference abstract [120]
covid-19 [112]
olfactory dysfunction [2]
OMT [3746]
osteopathic manipulative treatment [3766]
pilot study [193]
post covid [12]
pretest posttest design [214]

Abstract:

Background and/or Objectives: One of the first cardinal symptoms of a SARS-CoV-2 infection is sudden loss of smell and taste. Individuals usually regain their sense of smell; however, a small amount of the population have prolonged decrease, complete absence, or abnormalities of smell long after the infection has resolved. The objective of this study was to determine if Osteopathic Manipulative Therapy(OMT) has any effect on prolonged Post-COVID olfactory dysfunction. Design: This study represents a single-blinded pilot trial conducted during 2021 to examine the effects of a single treatment with OMT in individuals who have selfidentified prolonged post-COVID anosmia, hyposmia or parosmia (n=20). Setting: Two locations within Ohio University. Participants: Participants were required to show a positive COVID-19 test at least 14 days prior to participation in the study, at least 18 years old and report decreased or absent smell. Interventions: Patients were randomly assigned to either the OMT group or a placebo/light touch/sham group by a flip of the coin and subsequently underwent pre-treatment smell testing of 4 items (Orange, Red Onion, Bourbon, and Perfume) then treated based on group selection, then underwent post-treatment smell testing to determine change in olfactory function. Main Outcome Measures: Smell identification and change in smell intensity. Results: A Mann-Whitney test indicated that the post and pre-treatment differences in the correct smell intensity scores of red onions were significantly higher for participants who received OMT treatment (Mdn = 2.00) compared to participants who received a nonosteopathic treatment (Mdn=1.00), U=20, p=0.019, r=5. There was a correlation of an increase in smell intensity in 2 out of the 3 remaining smell items; the mean difference between pre-smell treatment and postsmell treatment in the OMT group was higher than in the placebo group. Conclusions: OMT is a potential treatment for individuals suffering from this PASC symptom and should be investigated further to determine the magnitude of OMT's effects on PASC in general.


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