Advanced search


Search results        Search results      Copy URL to E-Mail


The Effect of Facial Effleurage on Serum Complement C3 During Acute Rhinosinusitis: A Randomized, Controlled Study

Journal: The Journal of the American Osteopathic Association Date: 2020/12, 120(12):Pages: e78-e79. doi: Subito , type of study: randomized controlled trial

Full text    (https://www.degruyter.com/document/doi/10.7556/jaoa.2020.157/html)

Keywords:

C3 [2]
facial effleurage [4]
immune system [48]
randomized controlled trial [866]
rhinosinusitis [10]

Abstract:

Statement of Significance: Osteopathic Manipulative Treatments (OMTs) have long been used, but their mechanisms of action have been underexplored. We aimed to elucidate the immunological mechanism of Facial Effleurage (FE), a type of OMT, in acute rhinosinusitis. FE uses rhythmic pressure to refresh facial lymphatics and improve sinus mucus clearance; this could have a direct impact on the symptoms and immune system in rhinosinusitis patients. Acute rhinosinusitis, a common condition in ambulatory settings, is often treated with antibiotics. OMT offers adjunct or alternative non-pharmacological interventions. Understanding if FE treatment in rhinosinusitis patients can ameliorate symptoms by impacting their immune system is crucial to FE's more widespread use. Research Methods: The Edward Via College of Osteopathic Medicine Institutional Review Board approved all protocols. Ninety-one participants between the ages of 18 and 69 years were recruited from a community health clinic in Spartanburg, South Carolina. They were either determined to be healthy or diagnosed with acute rhinosinusitis by physicians at the clinic. Healthy participants were randomly assigned no treatment, Facial Effleurage, or sham treatment. Rhinosinusitis participants were randomly assigned antibiotics (standard-of-care), Facial Effleurage, sham treatment, antibiotics and Facial Effleurage, or antibiotics and sham treatment. The sham treatment mimics the patient's and physician's movements and hand placements of the Facial Effleurage procedure. However, the sham treatment does not use therapeutic pressure and, therefore, provides a control for Facial Effleurage without offering any therapeutic benefit. Antibiotics were started after treatment on the same day of their first visit. Serum samples were obtained prior to treatment, 1 hour following treatment, and at a 1-week follow-up visit. ELISAs were performed to obtain serum C3 concentrations. Data Analysis: Within Microsoft Excel, Student's t tests were performed to assess for significance between serum C3 concentrations in each group. Fisher's Exact Test was used to determine if there was a significant difference between the demographic categories of each treatment group. Graphs were created using GraphPad Prism 8.4.1 software. Significance was defined as a p-value < 0.05. Results: Rhinosinusitis patients who received Facial Effleurage had significantly lower serum C3 concentrations 1 hour after treatment compared with those who received the sham treatment (-373±778 μg/mL vs 761±1346 μg/mL, p = 0.0320). There were no other significant differences in average serum C3 concentrations in any other treatment group 1-hour post-treatment or 7-10 days post-treatment. There was no significant difference in average baseline C3 serum concentrations (p = 0.418) between healthy (2510±1353 μg/mL) and RS (2258±1476 μg/mL) participants. Conclusion: Facial Effleurage changes serum C3 concentrations as soon as 1-hour following treatment. This novel finding is the first evidence of a potential mechanism of action for Facial Effleurage and how it can provide this benefit to patients suffering from acute rhinosinusitis. We suggest Facial Effleurage, and other forms of Osteopathic Manipulative Treatment, should be used as an additional acute rhinosinusitis treatment. Further studies are needed to determine how long the immunological impact persists as well as other mechanisms of action of Facial Effleurage. A limitation of this study was the low sample size per group; more samples could have provided more statistical power to better detect additional significant differences between treatment groups. Another limitation is that we measured peripheral serum C3 concentrations and not what is occurring directly in the nasal mucosa, which might paint an even more interesting picture of the benefit of Facial Effleurage.


Search results      Copy URL to E-Mail

 
 
 






  • ImpressumLegal noticeDatenschutz


ostlib.de/data_ecatbhwpvxmydgqzsujf



Supported by

OSTLIB recommends