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Magnetic resonance imaging in the assessment of brain connectome in patients with chronic tension-type headache

Journal: European Journal of Neurology Date: 2021/07, 28(SUPPL 1):Pages: 647. doi: Subito , type of study: clinical trial

Full text    (https://onlinelibrary.wiley.com/toc/14681331/2021/28/7)

Keywords:

clinical trial [612]
functional connectivity [5]
connectome [1]
nuclear magnetic resonance imaging [1]
medial prefrontal cortex [1]
neuroimaging [2]
osteopathic manipulative treatment [2973]
conference abstract [108]
chronic tension headache [1]
chronic pain [204]

Abstract:

Background and aims: The determination of changes in functional connections is promising in forming a new view on the etiology and pathogenesis of tension-type headache (TTH) and makes it possible to develop effective treatment tactics for patients. The aim of the study was to asses changes in the connectome in patients with TTH before and after application of osteopathic correction. Methods: 24 patients (cf. age 32±5.6 years) with TTH were examined. Functional resting-state MRI was performed on a 1.5 T MR tomograph at two time points, before and immediately after osteopathic manipulation, respectively. Statistical processing and evaluation of the results of neuroimaging studies was carried out using the software package CONN V. 18, which serves to determine the relationships between different parts of the brain, the structure of various rest networks and working functional networks. We used the method of analysis based on the selection of the zone of interest. Results: According to the results of an intergroup statistical analysis (2-sample t-test), when comparing the functional connectivity of the brain at rest in the first and second time points, a weakening of the negative functional connection of the medial prefrontal cortex with the left upper parietal lobe was revealed (p<0.005). Conclusion: The results of the study indicate that patients with TTH before and after the application of osteopathic manipulation have differences in the functional activity of the brain.


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