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Effect of OMT in the Treatment of Initial Vascular Wall Alteration

Journal: The Journal of the American Osteopathic Association Date: 2008/08, 108(8):Pages: 421-422. doi: Subito , type of study: pretest posttest design

Full text    (https://www.degruyter.com/document/doi/10.7556/jaoa.2008.108.8.413/html)

Keywords:

cardiovascular system [12]
OMT [3102]
osteopathic manipulative treatment [3124]
pretest posttest design [140]

Abstract:

Hypothesis: Research studies document the relationship between vessels wall alterations and the modification of cardio-circulatory functions, as well as the association between a change of the endothelial carotid wall, hypertension and the occurrence of cardiologic events. So far, the efficacy of osteopathic treatment on the improvement of cardiovascular function concentrated has never been tested. Aim of the present study is to investigate the existence of an association between osteopathic treatment and intimae media thickness in terms of intermediate outcomes of long-term cardiovascular disorders at 12 months follow-up. Materials and Methods: Non-randomized trial, including a treated and control group of consecutive subjects resulting affected by vascular alterations at a cardiologic visit. Individual characteristics, including intimae media thickness, height, weight, rest rate, and use of prescribed drugs, were measured at entry and after 12 months follow-up. Osteopathic treatment was administered by a group of osteopaths. Pre-post differences at 12-months in intimae media thickness were used as primary endpoints. Statistical analysis was performed using univariate t tests and multivariate linear regression. Results: Out of a total of 63 patients entering the study, 31 were administered osteopathic treatment and followed up for 12 months. Univariate statistical analysis showed no significant imbalances among treated and control groups in terms of main characteristics measured at baseline. At the end of the follow-up, heart rate and osteopathic treatment were significantly associated to change in intimae media thickness. All the factors, including a change in pre-post measurements of main endpoints, were used as potential confounders in a multivariate linear regression. After adjusting for all such characteristics, osteopathic treatment was found to be significantly and independently associated to a change in intimae media thickness (mean difference between change in treated and control groups: -0.602; 95%c.i.:-0.745 – -0.459). Conclusions: Our study, targeting a selected population of patients affected by cardiovascular disorders, shows that after a one-year follow-up, as measured by main clinical parameters, osteopathic treatment is independently associated to an improvement in intimae media. However our approach, mainly exploratory and hypothesis generating, should be further extended to avoid the potential bias induced by the particular study population.


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