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Fibromyalgia Treatment Trial With Gabapentin and Osteopathic Manipulative Medicine

Journal: Journal of Osteopathic Medicine Date: 2009/08, 109(8):Pages: 429. doi: Subito , type of study: randomized controlled trial

Full text    (https://www.degruyter.com/document/doi/10.7556/jaoa.2009.109.8.425/html)

Keywords:

fibromyalgia [43]
gabapentin [5]
OMT [3746]
osteopathic manipulative treatment [3766]
randomized controlled trial [889]

Abstract:

Hypothesis: Intervention with gabapentin and osteopathic manipulative medicine (OMM) can improve the symptoms of fibromyalgia. Combined therapy can decrease the number and severity of tender points (TPs) and the overall pain level with greater efficacy than monotherapy. Subjects in the combined group will have greater improvement quality of life and function. Materials and Methods: Subjects between the ages of 18 and 65 years with fibromyalgia symptoms were recruited from Solano, Sonoma, and Contra Costa counties in Calif. Subjects who met inclusion criteria were enrolled, randomized to an arm and monitored at eight weekly intervals, receiving treatment during weeks 2-7. Treatment interventions consisted of OMM only, gabapentin only, or combined therapy of OMM and gabapentin. Results: 29 subjects completed the study. Subjective ability to perform ADLs (as measured by the Fibromyalgia Impact Questionnaire, FIQ) was significantly improved in the combined treatment group relative to monotherapy groups. Subjects receiving combined therapy had a 12% improvement in FIQ score, versus 8% in the gabapentin group and 2% in the OMM group. Subjects in the combined group also rated themselves with the greatest overall health improvement over the course of their 8-week participation in the study. Subjects in the combined treatment group also had the greatest decrease in number of tender points based on the 18-point American College of Rheumatology exam criteria. Conclusions: A combined therapy of OMM and gabapentin results in improvement of subjective and objectives measures relative to monotherapy in patients with fibromyalgia. Larger and longer trials are needed to optimize OMM treatment protocols and assess long-term outcomes.


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