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Salivary IgA Fluctuations in Response to Stress and Osteopathic Manipulative Treatment

Journal: The Journal of the American Osteopathic Association Date: 2009/01, 109(1):Pages: 41. doi: Subito , type of study: randomized controlled trial

Full text    (https://www.degruyter.com/document/doi/10.7556/jaoa.2009.109.1.40/html)

Keywords:

OMT [3102]
osteopathic manipulative treatment [3124]
randomized controlled trial [766]
saliva [7]
stress [89]

Abstract:

High levels of human salivary sIgA (s-IgA) have been shown to decrease the incidence of acquiring upper respiratory tract infections (URTI). In recent publications, Osteopathic Manipulative Treatment (OMT) has been shown to improve cardiac indices, increase lymph flow rates through the thoracic duct and decrease sympathetic tone in post-surgical and ICU patients. This information led us to hypothesize that perhaps OMT may also increase IgA levels in people under high levels of emotional and psychological stress, thereby enhancing immunity, and preventing an array of subsequent infections. The objective of this study was to determine if Osteopathic Manipulative treatments have any effect on salivary IgA levels. This open randomized controlled study consisted of 25 second year medical students: 12 students in the experimental group, matched with 13 in the control group. Before the experiment, all subjects submitted a saliva sample for a baseline IgA level. The experimental group went on to receive 20 minutes of OMT, while the control group studied in a separate area for 20 minutes. All subjects submitted a second saliva sample one hour after the 20 minute intervention. The IgA levels for both groups were recorded before the intervention (T1) and after the intervention (T2). Data were analyzed via 2×2 ANOVA GLM for repeated measures. The experimental group, who received OMT, displayed a significantly greater increase in salivary IgA levels after the intervention compared with the control (p<0.025). The study demonstrates the positive effect that Osteopathic Manipulative Treatment has on salivary IgA levels in persons enduring high stress states. This suggests that OMT may then have therapeutic preventative and protective effects on hospitalized patients, especially those requiring ventilator-assistance, as they are subject high levels of emotional and physiological stress, low levels of salivary IgA, and subsequent acquisition of URTI.


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