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Immediate Effects of Osteopathic Manipulative Treatments on Immune Function in a Healthy Population: A Pilot Study

Journal: The Journal of the American Osteopathic Association Date: 2006/08, 106(8):Pages: 472-473. doi: Subito , type of study: randomized controlled trial

Full text    (https://www.degruyter.com/document/doi/10.7556/jaoa.2006.106.8.471/html)

Keywords:

immune system [48]
OMT [3663]
osteopathic manipulative treatment [3685]
pilot study [186]
randomized controlled trial [866]

Abstract:

Objectives: The purpose of this pilot study was to investigate the immediate effects of Osteopathic Manipulative Treatment (OMT) on immune function in a healthy population. Methods: This was a prospective, randomized, blinded and controlled clinical trial. Fifty healthy individuals, ages 18 to 40, were recruited primarily from the UNTHSC campus. Exclusion criteria included any disease, treatment or habit that influences immune function and any condition for which OMT is contraindicated. Subjects were randomly assigned to one of two groups: OMT or Rest (control). Blood and saliva samples were collected pre- and post-intervention (thirty minutes of OMT or Rest). Samples were analyzed for a complete blood count (CBC) with a differential using a Coulter Counter, salivary IgA using ELISA, and B-lymphocyte percentages, and T-lymphocyte sub-population concentrations: CD4, CD8 and natural killer cells using flow cytometry. Results: Fifty subjects were recruited, 25 in each group. This study demonstrated the feasibility of this protocol. Additionally, strong relationships for future collaborations were developed. No statistically significant differences in outcome measures were identified between the two groups, nor were any apparent trends identified. Conclusion: Although this study proved the feasibility of this protocol and established a solid framework for future research, further studies must be conducted. It is imperative that the efficacy of OMT in acute and chronic infection, chronic pain, and immunocompromised populations continued to be studied. Animal studies have proven to be insightful, and should continue to provide valuable information on the mechanism of action of OMT. In addition, the long term results of osteopathic manipulative treatments over a longer period of time should be examined. This pilot study offers valuable information that should direct future studies.


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