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Clinical effectiveness of osteopathic treatment in chronic migraine: 3-Armed randomized controlled trial

Journal: Complementary Therapies in Medicine Date: 2015/04, 23(2):Pages: 149-156. doi: Subito , type of study: randomized controlled trial

Full text    (http://www.sciencedirect.com/science/article/pii/S0965229915000126)

Keywords:

osteopathic manipulative treatment [2973]
OMT [2951]
headache [127]
pain [1108]
sham therapy [4]
randomized controlled trial [710]
hit-6 [3]

Abstract:

Summary Objective To assess the effectiveness of OMT on chronic migraineurs using HIT-6 questionnaire, drug consumption, days of migraine, pain intensity and functional disability. Design 3-Armed randomized controlled trial setting: all patients admitted in the Department of Neurology of Ancona's United Hospitals, Italy, with a diagnosis of migraine and without chronic illness, were considered eligible for the study. Interventions Patients were randomly divided into three groups: (1) OMT+medication therapy, (2) sham+medication therapy and (3) medication therapy only. Patients received 8 treatments in a study period of 6 months. Main outcome measures Changing from baseline HIT-6 score. Results 105 subjects were included. At the end of the study, ANOVA showed that OMT significantly reduced HIT-6 score (mean change scores OMT–conventional care: −8.74; 95% confidence interval (CI) −12.96 to −4.52; p<0.001 and OMT–sham: −6.62; 95% CI −10.85 to −2.41; p<0.001), drug consumption (OMT–sham: RR=0.22, 95% CI 0.11–0.40; OMT–control: RR=0.20, 95% CI 0.10–0.36), days of migraine (OMT-conventional care: M=−21.06; 95% CI −23.19 to −18.92; p<0.001 and OMT–sham: −17.43; 95% CI −19.57 to −15.29; p<0.001), pain intensity (OMT–sham: RR=0.42, 95% CI 0.24–0.69; OMT–control: RR=0.31, 95% CI 0.19–0.49) and functional disability (p<0.001). Conclusions These findings suggest that OMT may be considered a valid procedure for the management of migraineurs. The present trial was registered on www.ClinicalTrials.gov (identifier: NCT01851148).


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